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Tuberculosis News
December 3, 2020

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updated 10:57pm EST

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Solving a Mystery: How the TB Bacterium Develops Rapid Resistance to Antibiotics

These slow growing bacteria have long puzzled TB researchers with their fairly rapid resistance to antibiotics. Researchers may have been barking up the wrong tree in exploring genetics, because the ...

New Cell Profiling Method Could Speed TB Drug Discovery

A new cell profiling technology combines high throughput imaging and machine learning to provide a rapid, cost-effective way to determine how specific compounds act to destroy the bacterium that ...

Dr. Jekyll and Mr. Hyde -- Enzyme Targeted by TB Antibiotic Later Stops the Drug Destroying It

Researchers have found that a key antibiotic widely used to treat drug-resistant tuberculosis does not work as expected - a finding which could be used to develop new ...

Blood Test for Eight Gene Signatures Can Predict Onset of Tuberculosis

Scientists have shown a blood test could predict the onset of tuberculosis three to six months before people become unwell, a finding which could help better target antibiotics and save countless ...

How an AI Solution Can Design New Tuberculosis Drug Regimens

With a shortage of new tuberculosis drugs in the pipeline, a software tool can predict how current drugs--including unlikely candidates -- can be combined in new ways to create more effective ...

T-Box Structure in Bacteria May Be Target for New Antibiotics

Researchers have uncovered the structure of a regulatory mechanism unique to bacteria, opening the door for designing new antibiotics targeted to ...

New Clinical Guideline for the Treatment and Prevention of Drug-Resistant Tuberculosis

Researchers have published an official clinical guideline on the treatment of drug-resistant tuberculosis ...

Boosting Host Immune Defenses to Treat Tuberculosis

A study suggests a new approach that might help treat Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis: making people's cells better at killing Mtb by harnessing RNA sensors ...

Using Whole-Genome Sequencing for Early Identification and Containment of AMR Pathogens

A study published today examines the evolutionary and epidemiologic history of an epidemic strain of extensively drug-resistant tuberculosis (XDR-TB) -- called LAM4/KZN. This strain was first ...

Anti-Arthritis Drug Also Stops Tuberculosis Bacillus from Multiplying in Blood Stem Cells

Immunologists have shown that a drug used to fight arthritis also stops the process that allows the tuberculosis bacillus to infect and hijack blood stem ...

Tuberculosis: New Insights Into the Pathogen

Researchers have gained new insights into the pathogen that causes tuberculosis. The work provides the basis for a new approach in antibiotic ...

Why HIV Patients Are More Likely to Develop Tuberculosis

Tuberculosis and HIV -- two of the world's deadliest infectious diseases -- are far worse when they occur together. Now researchers have pinpointed an important mechanism at work in this ...

A Quarter of the World's Population at Risk of Developing Tuberculosis

A new study has shown that probably 1 in 4 people in the world carry the tuberculosis bacterium in the body. The disease tuberculosis is caused by the bacterium Mycobacterium Tuberculosis, which ...

New Study Reveals How TB Bacteria May Survive in Human Tissues

Microbiologists have discovered that some pathogens depend on carbon monoxide to survive when other nutrients are not ...

First Impressions Go a Long Way in the Immune System

An algorithm that predicts the immune response to a pathogen could lead to early diagnosis for such diseases as ...

Waking Up Sleeping Bacteria to Fight Infections

Researchers have identified a mechanism of how sleepy bacteria wake up. This finding is important, as sleepy cells are often responsible for the stubbornness of chronic infections. Findings reveal ...

How Well TB Antibiotics Reach Their Targets

Scientists have developed a new technique that enables them to visualise how well antibiotics against tuberculosis (TB) reach their pathogenic targets inside human ...

Researchers Study Resistance to 'Protect' Anti-TB Drug

Scientists are trying to conserve the life-saving treatment bedaquiline, by studying how the bacterium that causes TB can develop resistance to this ...

New Arsenic-Based Broad-Spectrum Antibiotic

Antibiotic resistance is one of the biggest public health threats of our time. There is a pressing need for new and novel antibiotics to combat the rise in antibiotic-resistant bacteria. Researchers ...

TB: Promising New Drugs for Old Pathogen Mtb

Researchers are targeting a metabolic pathway, the dihydrofolate reductase pathway, crucial for amino acid synthesis to treat TB ...

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