Sickle Cell Anemia News
September 24, 2020

Top Headlines

How Dantu Blood Group Protects Against Malaria, and How All Humans Could Benefit

The secret of how the Dantu genetic blood variant helps to protect against malaria has been revealed for the first time. The team found that red ...

Targeting a Blood Stem Cell Subset Shows Lasting, Therapeutically Relevant Gene Editing

Researchers have used CRISPR-Cas9 to edit long-lived blood stem cells to reverse the clinical symptoms observed with several blood disorders, ...

Over-Conditioning Kills: Non-Traumatic Fatalities in Football Is Preventable

Most non-traumatic fatalities among high school and college football athletes do not occur while playing the game of football, but rather during ...

Early Clinical Trial Data Show Gene Therapy Reversing Sickle Cell Anemia

After over a decade of preclinical research and development, a new gene therapy treatment for sickle cell anemia (SCA) is reversing disease symptoms in two adults and showing early potential for ...
Latest Headlines
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Earlier Headlines

New Mobile Health Tool Measures Hemoglobin Without Drawing Blood

Researchers have developed a way to use smartphone images of a person's eyelids to assess blood hemoglobin levels. The ability to perform one of the most common clinical lab tests without a ...

Blood Transfusions: Fresh Red Blood Cells No Better Than Older Ones

Findings from the ABC-PICU study on critically ill children may alter policies at hospitals where fresh red cells are preferentially ...

Computer Model Could Help Test New Sickle Cell Drugs

A new computer model that captures the dynamics of the red blood cell sickling process could help in evaluating drugs for treating sickle cell ...

The Way Sickle Cells Form May Be Key to Stopping Them

Chemists are reporting a new finding on how sickle cells are formed, which may lead not only to stopping their formation, but to new avenues for making uniformly-sized nanoparticles for ...

New Method to Rapidly, Reliably Monitor Sickle Cell Disease

Researchers have developed a rapid and reliable new method to continuously monitor sickle cell disease using a microfluidics-based electrical impedance sensor. This novel technology can characterize ...

Blood Diseases Cured With Bone Marrow Transplant

Doubling the low amount of total body radiation delivered to patients undergoing bone marrow transplants with donor cells that are only 'half-matched' increased the rate of engraftment from ...

'Mutation Hotspot' Allows Common Fungus to Adapt to Different Host Environments

A new study finds that samples of Candida albicans from patients frequently lack one copy of a vital master regulator, which gives them flexibility to lose the other copy and adapt to different ...

Earlier Emergence of Malaria in Africa

Malaria, which claims hundreds of thousands of lives each year -- mainly children and especially in Africa -, is one of the leading causes of death by an infectious agent, the Plasmodium falciparum ...

Sickle Cell Disease and the Silent Stroke

Silent strokes are a common symptom of sickle cell disease, though they can be debilitating. Researchers recently showed that silent strokes may be caused by decreased oxygen delivery to a part of ...

To Be or Not to Be a White Blood Cell, That Is the Question

Japanese scientists have revealed a biological 'switch' that influences whether an immature blood cell would develop into a red blood cell or a subtype of white blood cell called myeloid ...

How Sickled Red Blood Cells Stick to Blood Vessels

A new study describes how sickled red blood cells get stuck in tiny blood vessels of patients with sickle-cell disease. The findings may help researchers predict more accurately when such a ...

New Link Between Hypoxia and Blood Clot Risk

Researchers have found how hypoxia (a low concentration of oxygen) decreases Protein S, a natural anticoagulant, resulting in an increased risk for the development of potentially life-threatening ...

DNA Repair After CRISPR Cutting Not at All What People Thought

Scientists discovered that a well-known DNA repair pathway, the Fanconi anemia pathway, surprisingly plays a key role in repairing double-strand DNA breaks created by CRISPR-Cas9. It acts as a ...

Treatments for Cancer and Sickle Cell Disease Deplete Germ Cells in Young Boys

Scientists have discovered that some treatments for cancer and sickle cell disease can destroy the germ cells that go on to develop into sperm in the testes of young boys. In some pre-pubescent boys, ...

Enzyme Identified as Possible Novel Drug Target for Sickle Cell Disease, Thalassemia

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell ...

Genome-Editing Tool Could Increase Cancer Risk

Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer, according to a new study. Researchers say that more studies are required in ...

'Incompatible' Donor Stem Cells Cure Adult Sickle Cell Patients

Doctors have cured seven adult patients of sickle cell disease, an inherited blood disorder primarily affecting the black community, using stem cells from donors previously thought to be ...

Healthy Red Blood Cells Owe Their Shape to Muscle-Like Structures

Researchers report that a protein called myosin IIA contracts to give red blood cells their distinctive shape. The findings could shed light on sickle cell diseases and other disorders where red ...

Solution to 50-Year-Old Mystery Could Lead to Gene Therapy for Common Blood Disorders

In a landmark study that could lead to new therapies for sickle cell anemia and other blood disorders, researchers have used CRISPR gene editing to introduce beneficial natural mutations into blood ...

A Breakthrough in Our Understanding of How Red Blood Cells Develop

For the first time, cellular machines called ribosomes -- which create proteins in every cell of the body -- have been linked to blood stem cell differentiation. The findings have revealed a ...

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